Studiebog
    Atkinson's Principles of Clinical Pharmacology

    Atkinson's Principles of Clinical Pharmacology

    Forfatter: info mangler
    Bog
    • Format
    • Bog, hardback
    • Engelsk

    Beskrivelse

    Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.

    Læs hele beskrivelsen
    Detaljer
    • SprogEngelsk
    • Sidetal762
    • Udgivelsesdato19-10-2021
    • ISBN139780128198698
    • Forlag Academic Press Inc
    • FormatHardback
    Størrelse og vægt
  • Vægt2290 g
    • coffee cup img
    10 cm
    book img
    21,6 cm
    27,6 cm

    Findes i disse kategorier...

    Se andre, der handler om...

    Sex Transport Pregnancy Drug-use Gender Development Drug development Hypersensitivity Macromolecules Oxidation Pediatrics Drug Hypersensitivity Pharmacokinetics Metabolism Pharmacology Genetic polymorphisms Clinical pharmacology Proteins Safety Lactation Ontogeny Protein binding Toxicology Monoclonal antibodies Inhibition Kinetics Drug allergy Pharmacogenomics Planning Hemodialysis Pharmacogenetics Allometry Drug Toxicity Teratogenesis Induction Drug Discovery Product Labeling Clinical trial Causality Program project Pharmacodynamics Pharmacovigilance Personalized medicine Precision Medicine Decisión Transgender Product development Scaling Functional magnetic resonance imaging (fMRI) Candidate selection Metabolic enzymes Cross-validation PBPK modeling Microbiome Compartmental models Drug disposition Liver disease Biomarkers ABC-Transporter Conjugation Drug-drug interactions Postmarketing surveillance Bi-specific antibodies Adverse events Renal function Polymorphisms Teratogenicity Identifiability Preclinical Portfolio Method validation Positron emission tomography (PET) Biosimilar Biologics Biopharmaceutical Immunoassays Residence time Drug response Therapeutic Drug Monitoring FDA Drug metabolism Risk Evaluation Pharmaceutical Target selection Efficacy Transporters Drug Safety Monitoring Adverse Drug Reactions Cytochrome P450 Liver function Digital Health Technologies Absolute bioavailability Active drug metabolites Active metabolites Adaptive Study Designs Adverse drug response BCS classification Area Under The Curve Area under the curve (AUC) Biophase Chromatographic assays Chromatographic interference Continuous Renal Replacement Therapy Calculation of replacement drug doses Distribution volume Development guidance and guidelines Drug-induced cancer Drug Regulation curative Drug dosing in kidney disease patients Drug metabolizing enzymes Drug therapy in older adults compartmental model First-in-human (FIH) Glomerular filtration rate estimates Cumulative effect First-pass metabolism “Flip-flop” models Glucuronosyl transferase Hepatic elimination Impact of kidney disease on nonrenal drug elimination Disease progress Intersubject variability Dose-effect In vitro-in vivo extrapolation Intercompartmental Clearance Elimination half-life lead identification Epoxide Hydrolase Elimination clearance esterase Ligand efficiency Factors affecting drug absorption Multiparameter optimization Medication use process Lead Optimization Michaelis Menten vs. first-order kinetics Medication Safety Model-informed drug development oxidase Need for polypharmacy Pharmacodynamic changes Physiological spaces NONMEM Polymerase chain reaction assays Idiosyncratic drug reactions Impact of kidney disease on drug distribution and absorption Real-world evidence Pharmacokinetic changes Imaging and target engagement Impact of kidney disease on renal drug elimination Residual variability Physiologically based models Sample analysis reactive metabolites Schedule dependence Renal drug elimination mechanisms Safety Signals Individualization of drug therapy Transferase Treatment of drug toxicity Learn and confirm Solute carrier transporter symptomatic Target concentration strategy Microdose Physiokinetics Physiologically based pharmacokinetics Noncompartmental model Medication use evaluation (MUE) Sample instability nonclinical Nonlinear mixed effect modeling Population pharmacokinetics Regulatory assessment Plateau principle Relative Bioavailability Swiss Cheese Model

    Velkommen til Saxo – din danske boghandel

    Hos os kan du handle som gæst, Saxo-bruger eller Saxo-medlem – du bestemmer selv. Skulle du få brug for hjælp, sidder vores kundeservice-team klar ved både telefonerne og tasterne.

    Om medlemspriser hos Saxo

    For at købe bøger til medlemspris skal du være medlem af Saxo Premium, Saxo Shopping eller Saxo Ung. De første 7 dage er gratis for nye medlemmer. Medlemskabet fornyes automatisk og kan altid opsiges. Læs mere om fordelene ved vores forskellige medlemskaber her.

    Machine Name: SAXO081