Treatment of Acute Leukemias : New Directions for Clinical Research

I: Diagnosis, Classification, and Prognosis.- 1 Classification of Acute Leukemias: Perspective 1.- 2 Classification of Acute Leukemias: Perspective 2.- II: Chemotherapeutic Strategies.- 3 Biology and Treatment of Infant Leukemias: Perspective 1.- 4 Biology and Treatment of Acute Leukemias in Infants: Perspective 2.- 5 Treatment of Childhood Acute Lymphoblastic Leukemia.- 6 Treatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium Perspective.- 7 Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future Directions.- 8 Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children's Cancer Group Trials.- 9 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1.- 10 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2.- 11 Central Nervous System-Directed Therapy for Acute Lymphoblastic Leukemia.- 12 Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia.- 13 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1.- 14 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2.- 15 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1.- 16 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2.- 17 Treatment of Acute Myeloid Leukemia in Children.- 18 Treatment of Childhood Acute Myeloid Leukemia.- I. Acute Myeloid Leukemia in Adults.- 19 Therapy of Acute Myeloid Leukemia in Adults.- 20 Treatment of Adult Acute Myelogenous Leukemia.- J. Acute Promyelocytic Leukemia.- 21 Acute Promyelocytic Leukemia: Perspective 1.- 22 Acute Promyelocytic Leukemia: Perspective 2.- K. Childhood Leukemias in Underprivileged Countries.- 23 Treatment of Childhood Leukemias inUnderprivileged Countries.- 24 How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations.- III: Antileukemic Drugs.- 25 Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia.- 26 Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia.- 27 Asparaginase.- 28 Asparaginase Treatment.- 29 Antipurines in Childhood Acute Lymphoblastic Leukemia.- 30 Antipurines.- 31 Etoposide in Acute Leukemias: Therapeutic and Pharmacokinetic Considerations.- 32 Etoposide and Teniposide: Clinical Applications with a Focus on Leukemia.- IV: Hematopoietic Stem Cell Transplantation.- 33 Hematopoietic Stem Cell Transplantation: Perspective 1.- 34 Hematopoietic Stem Cell Transplantation: Perspective 2.- V: Biologic Treatments.- 35 Hematopoietic Growth Factors in Patients with Acute Leukemia.- 36 Hematopoietic Growth Factor Treatment in Leukemia.- 37 Immunotherapy of Leukemia.- 38 Therapy of Acute Leukemia with Monoclonal Antibodies and Immunoconjugates.- VI: Drug Resistance.- 39 Drug Resistance in Acute Leukemias.- 40 Drug Resistance in Acute Leukemia.- VII: Minimal Residual Disease.- 41 Minimal Residual Disease.- 42 Molecular Monitoring of Minimal Residual Disease.