MRNA Metabolism and Post–Transcriptional Gene Regulation

mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION



Edited by Joe B. Harford and David R. Morris



Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted.



mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions.



Topics covered include:

* RNA structure

* Mammalian RNA editing

* RNA export from the nucleus

* The fundamentals of translation initiation

* Control of mRNA decay in plants

* mRNA metabolism and cancer

* Control of mRNA stability during herpes simplex virus infection

* Regulation of mRNA expression in HIV-1 and other complexretroviruses

* Nucleases

* RNA localization



A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.