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Kat's parents are accosted while shopping. Though they were unable to change on anything but a full moon, the wolf took over and spared them from being the victims of a horrid crime. With the strength only afforded by human flesh, they find they can change on demand just like Kat. Jennifer and Kat travel to New Castle for a visit where Kat's mom and dad meet their newly adopted daughter. Together, the family goes hunting, bringing down a local gang, leaving ample carnage behind. A werewolf suspected of going astray is targeted by The Agency. Upon careful examination, they find a sinister plan at work. Vitamin C, the drug dealer who took Jennifer as payment for her mother's debt finds himself having to answer for his wrongdoings. Packed with action, blood, meat torn from the bones, Lupine 3 delivers in returning werewolves to the horror genre without losing its humanity.