Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

- Concepts, Methods and Translational Sciences

Forfatter: info mangler
Bog
  • Format
  • Bog, paperback
  • Engelsk

Beskrivelse

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.

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Størrelse og vægt
  • Vægt1460 g
  • coffee cup img
    10 cm
    book img
    19,1 cm
    23,4 cm

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    Distribution Blood Drugs Enzymes Gene therapy Mass spectrometry Oxidation Peptides Risk assessment Cerebrospinal Fluid Pharmacokinetics Cholestasis Metabolism Immune response Cellular immunity In vitro Proteins Cytochrome P-450 Metabolites Quality control Workflow Animal models Monoclonal antibodies Urine Derivatization Pharmacogenomics Accelerator mass spectrometry Biotransformation Supercritical fluid chromatography Clinical trial Biocatalysis Absorption Drug transporters Drug discovery and development PK/PD CRISPR/CAS9 Transgenic Genome editing Protein quantification Intravenous LC-MS/MS Humoral immunity Biomarkers CRISPR-Cas9 Drug-drug interactions Stable isotope Deuterium Clearance IL-6 Knockout High-resolution mass spectrometry Oncolytic virus Background Subtraction Transcriptomics Fusion proteins Immunogenicity Quantitative proteomics Traditional Chinese Medicine Bioanalysis Nephrotoxicity Biological specimen Organ on a chip Drug metabolism Metabolite identification Immune checkpoint inhibitors Clinical Transporters LC-MS Cytochrome P450 Therapeutic proteins Forensics UGT XO CAR T PBPK FMO Stereoselectivity MRM Bioactivation ADME Absolute bioavailability Acyl glucuronide and excretion (ADME) AOX1 Aldehyde oxidase (AO) Antidrug antibody AKR1C3 CES1 Chimeric Chiral Drug Covalent binding CES2 Cytochrome P450 3A4 (CYP3A4) deuterated drug Drug-induced kidney injury (DIKI) Drug-drug interactions (DDI) Data-dependent acquisition Enzyme induction Chiral Inversion Cytochrome P450 (P450) Exposure comparison DDI Drug-induced liver injury (DILI) Drug metabolizing enzymes Fraction metabolized (fm) Dosing regimen Drug-drug interaction (DDI) FIH Flavin monooxygenase (FMO) H/D-exchange Doping control Humanized Human liver microsomes (HLM) In vitro-in vivo extrapolation Dose-to-human LC-NMR Isotope Effect Metabolite safety assessment Microtracer FDA and ICH guidance document Metabolite production scale-up mitochondrial toxicity MSE and SWATH MAO-B mechanism-based inactivation Metabolites in safety testing Metabolite synthesis MHC I MHC II Non-CYP enzymes mist Orthogonal separation Preclinical immunogenicity Proximal tubule toxicity QSP Physiological-based pharmacokinetic (PBPK) modeling RNA Therapeutics Reaction phenotyping reactive metabolites Isotope pattern filtering Reversible inhibition Structure elucidation by NMR T-cell engaging bispecific molecules Transporter inhibition Mass defect Microbial Biotransformation Stereoselective analysis MAO-A Metabolite prediction software Metabolite purification Microphysiological systems (MPS) Physiologically based pharmacokinetics Metabolite identification (MetID) physiologically based pharmacokinetic model Silensomes Small Molecule Drugs Structural characterization UDP-glucuronosyltransferase PKPD/E TMDD

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