Cardiovascular and Metabolic Disease

Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book is the first that brings together the most recent information on obesity, hypertension and insulin resistance and the links that exist between them in order to provide a complete picture of drug discovery for these disorders. The opening chapter introduces the molecular links between obesity and metabolic dysfunction before the main three sections present obesity, hypertension and diabetes in turn. Chapters are contributed by leaders in the field from both academia and industry and will cover biomarkers, risk factors, gene-environment interactions, therapies and the various types of animal models that have been used to study each disease. Case studies describing the implementation of the models in drug development further enhance the book's usefulness as a comprehensive guide for medicinal and pharmaceutical chemists.