Anaerobiosis and Stemness

- An Evolutionary Paradigm for Therapeutic Applications

  • Format
  • Bog, hardback
  • Engelsk

Beskrivelse

Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells.  Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation.  This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration.

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Detaljer
  • SprogEngelsk
  • Sidetal326
  • Udgivelsesdato01-12-2015
  • ISBN139780128005408
  • Forlag Academic Press Inc
  • FormatHardback
Størrelse og vægt
  • Vægt720 g
  • coffee cup img
    10 cm
    book img
    15,1 cm
    22,9 cm

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    Cancer Commitment Survival Regeneration Differentiation Ischemia Oxygen Cell migration Stem cells Phenotype Oxidative stress Cell cycle Mitochondria Genes Maintenance Anaerobiosis Anoxia Mitosis Glycolysis ABC transporters Self-renewal Sirtuin Signaling pathways Warburg Effect Hypoxia Cancer stem cells Progenitors Stem cell Epigenetic Markers Fatty acid oxidation Hypoxemia /HOX/ genes Phase AMPK Cell therapy Epigenetic regulation Quiescence MiRNAs Progenitor cells Toolkit Wnt signaling MTOR Pluripotency Enrichment Microenvironment OXPHOS Niche Stemness Active proliferation Aerobiosis Anaerobic mitochondria Atmospheric oxygen concentration Anaerobyosis Committed progenitors Committed progenitor cell Energetic homeostasis Ex vivo G0 HIFs Functional heterogeneity Hypoxic response Hypoxia inducing factors (HIF)Immuno-phenotype Last eukaryote common ancestor (LECA)OXPHOS Eukaryote evolution First eukaryote common ancestor (FECA)Last eukaryote common ancestor (LECA)Meiosis First eukaryote common ancestor (FECA)Hydrogenozomes First eukaryote common ancestor (FECA)Last eukaryote common ancestor (LECA)Microaerobiosis First eukaryote common ancestor (FECA)Last eukaryote common ancestor (LECA)Multidrug resistance FoxO First eukaryote common ancestor (FECA)Glycolysis Functional definition Microaerobiosis Normoxia Normoxemia Physioxia Oxidative phosphorylation Proterozoic ocean Polycomb and trithorax proteins Side population Proliferative capacity Multipotent progenitors Oxygen concentration in situ ROS/RNS Mitochondria evolution

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