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Table of Content.- 1 History of Tobacco.- 2 Epidemiology of Tobacco Dependence.- 3 Tobacco Constituents and Additives.- 4 Pharmacology and Pharmacokinetics of Nicotine.- 5 Smoking and Lung Disease.- 6 Cardiovascular Disease, Disturbances of Blood Coagulation and Fibrinolysis.- 7 Other Organ Systems.- 8 Smoking and Pregnancy.- 9 Passive Smoking.- 10 Non-drug Treatments to Promote Smoking Cessation.- 11 Pharmacotherapy of Nicotine Dependence.- 12 Primary Prevention.- 13 Tobacco Industry, Advertising and Advertising Bans.- 14 Society, Politics and the Tobacco Industry.- 15 Appendix: Experiences from the Erfurt Smoker Counselling Centre.