Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms

  • Format
  • Bog, paperback
  • Engelsk

Beskrivelse

Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences.

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Detaljer
  • SprogEngelsk
  • Sidetal780
  • Udgivelsesdato26-06-2020
  • ISBN139780128224816
  • Forlag Academic Press Inc
  • FormatPaperback
Størrelse og vægt
  • Vægt2200 g
  • coffee cup img
    10 cm
    book img
    21,6 cm
    27,6 cm

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    Migration Calcium Nanotechnology Environment Inflammation Nanoparticles. Nucleic acids Ros Toxicity Neurotoxicology In vitro Metabolic Diseases Macrophage Carcinogenesis Stem cells Oxidative stress Manganese Superoxide Energy metabolism Apoptosis Autophagy Biomedicine Free Radicals Glutathione Necrosis Oximetry Regenerative Medicine Ecotoxicology Zebrafish Particulate Matter Reactive Oxygen Species Neuroprotection ESR Zinc oxide nanoparticles Hepatotoxicity Graphene-based materials Inflammatory bowel disease Mechanisms Cytotoxicity Stress response Nanomaterials Living systems Programmed cell death Oxidative damage Mechanism Intracellular distribution UPR Prostate cancer Nanomaterial Lipid peroxidation Drug-Delivery Immunotoxicity Phototoxicity Cellular signaling ER stress Nanotoxicology P53 Genotoxicity Nanoparticle Nanotoxicity Mitochondrial Dysfunction Unfolded Protein response Anticancer H2O2 Reactive nitrogen species Cellular processes FDA Perforin Reactive Oxygen Species ROS Oh Reactive nitrogen species (RNS) Liver function Hyperbaric oxygen therapy (HBOT) 1O2 3Rs AgNPs Antioxidant mechanisms Antipersister activity Antioxidant system Cell damage Cell death mechanisms Center for Drug Evaluation and Research (CDER) Breakthrough therapy (BT) designation DA autoxidation Center for Biologics Evaluation and Research (CBER) Cell toxicity Cellular toxicity Chelerythrine Chronic toxicities Endoplasmic reticulum (ER) stress Human HaCaT keratinocytes Hydroperoxides Immuno-spin trapping Human nanofoods Highly reactive molecules Hydroxyl Radicals Lipid accumulation FDA drug library Magnetic resonance modalities Manganism living organisms O2•- Manganese stress Granzyme Oxidative/antioxidative system NADPH-dependent p450 reductase Nanoparticle (NP) ?H2AX assay neutrophil Persisters Potential biomarkers Regulatory T cells (Tregs) Polynitrogen manganese complexes Protective effect ROS regulation Subcellular targeting ROS generation Immunoregulatory Total Antioxidant Capacity TiO2NPs Xenobiotic metals Mitotic catastrophe Nanoparticle cellular uptake Nanoparticles (NPs) Oxidative DNA damage Misfolded protein Nox4 Psoriatic dermatitis (PD) P38 ROS pathways tissue pathology Redox imaging Xenobiotic heavy metals ROS/RNS imaging TNF-a

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