Excerpt from Year-Book of Pharmacy: Comprising Abstracts of Papers Relating to Pharmacy, Materia Medica, and Chemistry, Contributed to British and Foreign Journals, From July 1, 1871, to June 30, 1872, With the Transactions of the British Pharmaceutical Conference
The bromine... derivative of camphor has lately been employed in Brussels and also in America as a sedative to the nervous system. This body is formed by the action of bromine on camphor. It crys tallises in colourless needles, and has the composition 020 H15 Br It is given in does of two to five grains, and has been favourably reported On by Dr. Hammond in New York. Prof. Maisch has given full details Of its preparation and properties.
Chloral seems to have definitely taken its place as a permanent article Of the material medica. It is now met with in commerce in a sufficient state Of purity. It is true that samples are sometimes met with which are very pungent, and after being kept for a while emit an acid vapour On opening the bottle; but this seems to arise not so much from any foreign body left in the product by its manu facture, as from a slight deficiency Of the water of hydration, the trace of free chloral probably undergoing some decomposition. Certainly the chief difficulty in the preparation of the hydrate is to Obtain it with the exact amount Of water necessary; a slight excess causing an appearance Of deliquescence, while any deficiency leads to the pungency, which is, if anything, more Objectionable. Dr. Squibb, who last year gave some valuable details of the method Of manufacture, has this year given us the results Of his experience on the best means of testing the quality of the product. He, in common with others, rejects the chloroform tests as of little value, and looks rather to the detection Of secondary products which may remain as impurities from imperfect manufacture.
The crotonic chloral, first Obtained by the action of chlorine on aldehyde (see Year Book, 1871, p. Has been found to possess Valuable therapeutical properties, distinct from those of ordinary chloral. It has been administered in cases of insanity with peculiar benefit, and from its specific power of narcotising the fifth part Of' cerebral, nerves, it is likely to prove a useful remedy in neuralgia. It has been given in doses of 5 to 10 grains.
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