The Future of Predictive Safety Evaluation

- In Two Volumes Volume 1

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The Future of Predictive Safety Evaluation
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Format:
Bog, paperback
Udgivelsesdato:
13-10-2011
Sprog:
Engelsk
Udgave:
Softcover reprint of the original 1st ed. 1986.
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A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.

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Udgivelsesdato:
13-10-2011
ISBN13:
9789401083362
Vægt:
373 g
Dybde:
13 mm
Bredde:
155 mm
Højde:
235 mm
Forlag:
Springer
Format:
Paperback
Forfattere
Bibliotekernes beskrivelse The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. 1 Paperback / softback 224 p.

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