Excerpt from The American Druggist, Vol. 18: An Illustrated Monthly Journal of Pharmacy, Chemistry and Materia Medica; January, 1889
Soluble substances should always be dissolved before the medicine passes into the patient's hands, when it is possible to do so, and it is well... , and may be necessary, to use a little heat to accomplish this Object, but this must not be done when there is more of the substance than can be retained in solution at ordinary temperature, for when the liquid cools the surplus quantity will be deposited as crystals on the side of the bottle in a condition in which it will be al most impossible for the patient to take it.
When, therefore, the solid be in excess of the solvent, it must be reduced to the finest possible state of division, and rubbed or shaken u with the liquid, and the direction to shake the bottle be a ded.
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