Small Molecule Drug Discovery

- Methods, Molecules and Applications

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Small Molecule Drug Discovery
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  • Leveringstid 5-7 hverdage
  • Forventet levering 18-12-2019
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Format:
Bog, paperback
Udgivelsesdato:
02-12-2019
Sprog:
Engelsk
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Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.

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Udgivelsesdato:
02-12-2019
ISBN13:
9780128183496
Bredde:
191 mm
Højde:
235 mm
Format:
Paperback
  • Forfattere

  • Bibliotekernes beskrivelse

    Approx. 165 illustrations (15 in full color); Illustrations, unspecified

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