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Resistance of Cancer Cells to CTL-Mediated Immunotherapy

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Resistance of Cancer Cells to CTL-Mediated Immunotherapy
  • Forlagets pris kr. 1.509,95
  • Leveringstid 2-4 uger
  • Forventet levering 18-07-2018
Bog, paperback (kr. 1.019,95) (kr. 1.019,95)
  1. Beskrivelse

    This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. 1 Paperback 4 Tables, black and white; 27 Illustrations, color; 11 Illustrations, black and white; XIX, 353 p. 38 illus., 27 illus. in color.

  2. Yderligere info
    Udgivelsesdato:
    17-10-2016
    Sprog:
    Engelsk
    ISBN13:
    9783319380674
    Sidetal:
    372
    Vægt:
    670 g
    Bredde:
    155 mm
    Længde:
    235 mm
    Nummer i serien:
    7
    Mærkat:
    Bog, paperback
    Format:
    Paperback
    Udgave:
    Softcover reprint of the original 1st ed. 2015
    • Bibliotekernes beskrivelse

      This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

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