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Bog, paperback Resistance of Cancer Cells to CTL-Mediated Immunotherapy af Benjamin Bonavida

Resistance of Cancer Cells to CTL-Mediated Immunotherapy (Resistance to Targeted Anti Cancer Therapeutics, nr. 7)

(Bog, paperback)

11 black & white illustrations, 27 colour illustrations, 4 black & white tables, biography

11 black & white illustrations, 27 colour illustrations, 4 black & white tables, biography

Produktdetaljer:

Sprog:
Engelsk
ISBN-13:
9783319380674
Sideantal:
372
Udgivet:
04-11-2016
Udgave:
Softcover reprint of the original 1st ed. 2015
Nr. i serien:
7
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Forlagets beskrivelse
11 black & white illustrations, 27 colour illustrations, 4 black & white tables, biography
Bibliotekernes beskrivelse
This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

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