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Bog, paperback Resistance of Cancer Cells to CTL-Mediated Immunotherapy af Benjamin Bonavida

Resistance of Cancer Cells to CTL-Mediated Immunotherapy (Resistance to Targeted Anti Cancer Therapeutics, nr. 7)

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This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized ca... Læs mere

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. In order for CTL... Læs mere

Produktdetaljer:

Sprog:
Engelsk
ISBN-13:
9783319380674
Sideantal:
372
Udgivet:
17-10-2016
Udgave:
Softcover reprint of the original 1st ed. 2015
Nr. i serien:
7
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Forlagets beskrivelse
This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. 4 Tables, black and white; 27 Illustrations, color; 11 Illustrations, black and white; XIX, 353 p. 38 illus., 27 illus. in color.
Bibliotekernes beskrivelse
This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

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