p53 Protocols
Format:
Bog, hardback
Udgivelsesdato:
01-06-2003
Sprog:
Engelsk
  • Beskrivelse
  • Yderligere info
  • Anmeldelser

Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of this protein. Several unique properties of p53 posed a challenge to understa- ing its normal function in the initial phase of its research. The low levels of p53 in normal cells, its stabilization under situations of genotoxic stress, induction of growth arrest, and apoptosis with stabilization of the protein, obstructed the visibility of its normal, unmutated function. The property of p53 that can sense a promoter and transactivate or inhibit is still not well understood. It is still not known whether it is the absence of the protein that causes tumorigenesis, or if its mutants have a dominant role in inducing cancer. p53 Protocols comprises eighteen chapters for the study of the diverse properties of p53 and related proteins. The methods included are invaluable for delineating the function of other proteins that may function as tumor suppr- sors or growth suppressors. The chapters are not presented in any schematic order, for the importance and diversity of the functions of p53 make it imp- sible to organize them suitably. We have made a sincere effort to collect the methods most useful to those investigators working on tumor suppressors or growth suppressors. The purpose of p53 Protocols is not only to provide investigators with methods to analyze similar biochemical functions, but also to familiarize them with the associated problems that arose during the course of investigations.

Vis mereVis mindre

ISBN13:
9781588291066
Vægt:
608 g
Dybde:
21 mm
Bredde:
152 mm
Højde:
229 mm
Forlag:
Humana Press
Format:
Hardback
  • Forfattere

    Vis mereVis mindre

    Vis mereVis mindre

    • Leveringstid 4-6 hverdage
    • Forventet levering 01-08-2019

    på lager

    Fandt du ikke hvad du søgte?

    Hvis denne bog ikke er noget for dig, kan du benytte kategorierne nedenfor til at finde andre titler. Klik på en kategori for at se lignende bøger.

    Velkommen til Saxo

    Du har nu adgang til din konto hos Saxo, og kan se alle oplysninger om dit medlemskab, dine
    ordrer og din digitale boghylde under "Mit Saxo".

    Som tak for, at du har aktiveret dit medlemskab, har vi valgt at give dig fri læsning hele
    sommeren. Dvs. at du frit kan tilgå de mere en 50.000 bøger i Saxos app, samt købe bøger til
    vores altid lave medlemspris og fri fragt her på Saxo.com hele juli. Din næste medlemsbetaling
    vil først falde i august.

    Vi glæder os meget til at byde dig velkommen i vores univers, og håber at du kommer godt i
    gang med Saxo Premium.

    God sommer og god læselyst!

    Med venlig hilsen Saxo

    Kom i gang nu!