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Metallomics

Metallomics

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  • Forlagets pris kr. 1.819,95
  • Leveringstid 2-4 uger
  • Forventet levering 25-05-2018
Bog, hardback (kr. 1.214,95)
  1. Beskrivelse

    As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. 1 Hardback 76 Illustrations, color; 61 Illustrations, black and ... Læs mere

    Udgivelsesdato:
    10-03-2017
    Leveringstid:
    2-4 uger
    Rating:
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  2. Yderligere info
    Udgivelsesdato:
    10-03-2017
    Sprog:
    Engelsk
    ISBN13:
    9784431564614
    Sidetal:
    370
    Vægt:
    760
    Bredde:
    155
    Længde:
    235
    Mærkat:
    Bog, hardback
    Format:
    Hardback
    Udgave:
    1st ed. 2017
    • Bibliotekernes beskrivelse

      This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

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