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Bog, hardback Human Retrotransposons in Health and Disease af Gael Cristofari

Human Retrotransposons in Health and Disease

- 2017

(Bog, hardback)

6 black & white illustrations, 26 colour illustrations, 26 colour tables, biography

6 black & white illustrations, 26 colour illustrations, 26 colour tables, biography

Produktdetaljer:

Sprog:
Engelsk
ISBN-13:
9783319483436
Sideantal:
250
Udgivet:
31-12-2016
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kr. 1.619,95
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31-12-2016
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11-01-2017
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Forlagets beskrivelse
6 black & white illustrations, 26 colour illustrations, 26 colour tables, biography
Bibliotekernes beskrivelse
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80's. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.

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