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Formulation of Phenytoin Complexes for Dissolution Enhancement

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Formulation of Phenytoin Complexes for Dissolution Enhancement
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  • Forventet levering 01-10-2018
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  1. Beskrivelse

    Phenytoin Inclusion complex prepared by microwave method was used for preparation of FDT by different superdisintegrants by direct compression method. From that the cross-povidone (5%) containing inclusion complex was maximum DT, Wetting time and In-vitro drug release. The FDT containing 1:2 ratio complexes and 5% crospovidone give minimum DT and Wetting time. Then 32 full factorial designs were applied and the tablets were synthesized using different proportions of inclusion complex and crospovidone (%) by direct compression technique. The optimum ratio was 1:2 and 5% which produced highest DT (10.01 sec), Wetting time (9.45 sec.) and cumulative percent drug release (99.51% at 40 min). The solubility and dissolution pattern of Phenytoin were found to be carrier ratio dependent. From evaluation parameters and formulation characterization, it can be concluded that solubility of drug was improved by MW method compared to SE method and pure drug. The tablet contain optimum ratio of inclusion complex and optimum concentration of superdisintegrants give maximum drug release in minimum time period.

  2. Yderligere info
    Udgivelsesdato:
    01-05-2014
    Sprog:
    Engelsk
    ISBN13:
    9783659537059
    Sidetal:
    152
    Vægt:
    236 g
    Dybde:
    9 mm
    Bredde:
    152 mm
    Højde:
    229 mm
    Mærkat:
    Bog, hæftet
    Format:
    Hæftet
  3. Anmeldelser

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