Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine.From Smart Grid to Internet of Energy covers novel and emerging metering and monitoring technologies, communication systems, and technologies in smart grid areas to present a valuable reference for readers from various engineering backgrounds. Considering relevant topics on the essentials of smart grids and emerging wireless communication systems, such as IEEE 802.15.4 based novel technologies, cognitive radio networks and Internet of Energy, this book offers a discussion on the emerging trends and research direction for communication technologies. The book includes research concepts and visualization of smart grids and related communication technologies, making it a useful book for practicing network engineers.Entropy Analysis in Thermal Engineering Systems is a thorough reference on the latest formulation and limitations of traditional entropy analysis. Yousef Haseli draws on his own experience in thermal engineering as well as the knowledge of other global experts to explain the definitions and concepts of entropy and the significance of the second law of thermodynamics. The design and operation of systems is also described, as well as an analysis of the relationship between entropy change and exergy destruction in heat conversion and transfer. The book investigates the performance of thermal systems and the applications of the entropy analysis in thermal engineering systems to allow the reader to make clearer design decisions to maximize the energy potential of a thermal system.
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