Chromosomal Instability in Cancer Cells

- Chromosomal Instability in Cancer Cells

af

indgår i serie RECENT RESULTS IN CANCER RESEARCH


Chromosomal Instability in Cancer Cells
  • Leveringstid 2-4 uger
  • Forventet levering 17-03-2020
Format:
Bog, paperback
Udgivelsesdato:
22-10-2016
Sprog:
Engelsk
Udgave:
Softcover reprint of the original 1st ed. 2015.
  • Beskrivelse
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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

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Udgivelsesdato:
22-10-2016
ISBN13:
9783319349626
Vægt:
3577 g
Dybde:
12 mm
Bredde:
155 mm
Højde:
235 mm
Forlag:
Springer
Nummer i serien:
200
Nummer i serien:
200
Format:
Paperback
Forfattere
Bibliotekernes beskrivelse This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. 1 Paperback / softback 39 Illustrations, color; VII, 224 p. 39 illus. in color.

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