Caveolins and Caveolae

- Roles in Signaling and Disease Mechanisms

af

indgår i serie ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY


Caveolins and Caveolae
  • Leveringstid 5-7 hverdage
  • Forventet levering 27-11-2019
Format:
Bog, hardback
Udgivelsesdato:
30-01-2012
Sprog:
Engelsk
Udgave:
2012.
  • Beskrivelse
  • Yderligere info
  • Anmeldelser

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

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Udgivelsesdato:
30-01-2012
ISBN13:
9781461412212
Vægt:
567 g
Dybde:
15 mm
Bredde:
178 mm
Højde:
254 mm
Nummer i serien:
729
Nummer i serien:
729
Format:
Hardback
  • Forfattere

  • Bibliotekernes beskrivelse

    Utilizing modern electron microscopy techniques, this book discusses pleiotropic functions of caveolae and caveolin proteins, and offers a thorough presentation of the role and function of caveolae and caveolins in cell signaling and human disease mechanisms. 1 Hardback 3 Tables, black and white; 1 Illustrations, color; 26 Illustrations, black and white; XX, 184 p. 27 illus., 1 illus. in color.

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