Carbohydrate-Based Vaccines

- From Concept to Clinic

af

indgår i serie ACS SYMPOSIUM SERIES


Carbohydrate-Based Vaccines
Format:
Bog, hardback
Udgivelsesdato:
10-10-2019
Sprog:
Engelsk
  • Beskrivelse
  • Yderligere info
  • Anmeldelser

The past three decades have witnessed the development and regulatory approval of glycoconjugate vaccines against several medically important bacterial pathogens, including Haemophilus influenzae type b, Streptococcus pneumoniae, Neisseria meningitides, and Salmonella typhi. Immunologic protection against these and many other bacterial diseases is mediated through opsonophagocytic antibodies directed against the surfacecarbohydrates that define the bacterial serogroup or serotype and serve as virulence factors. These vaccines are composed of bacterial capsular polysaccharides chemically conjugated to immunogenic carrier proteins. Given that the diseases caused by these bacterial pathogens are most pronounced in infants and young children, the development of theglycoconjugate vaccine technology has had a considerable impact on public health. Many of the chapters in this volume were assembled as a follow-up from a symposium entitled "Carbohydrate-Based Vaccines and Adjuvants" which took place at the 254th American Chemical Society National Meeting held in Washington, DC (August 2017). The symposium was sponsored by Pfizer and the Carbohydrate (CARB) and Biotechnology (BIOT) divisions. This book, therefore, reflects the importance of this field toward design, development, manufacture and licensure of the complex carbohydrate-based(glycoconjugate) vaccines. The book has been organized into thirteen chapters, which cover a comprehensive landscape including the clinical history, design, development, chemistry, manufacturing and control (CMC) aspects, pre-clinical assays, adjuvants and the various approaches used to develop carbohydrate-based vaccines.

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Udgivelsesdato:
10-10-2019
ISBN13:
9780841233379
Vægt:
822 g
Dybde:
31 mm
Bredde:
160 mm
Højde:
230 mm
Format:
Hardback
  • Forfattere

  • Bibliotekernes beskrivelse

    This book explores the development of carbohydrate-based vaccines, covering the clinical history, design, development, manufacturing and control (CMC) aspects, and beyond.

Vis mereVis mindre

Vis mereVis mindre

Carbohydrate-Based Vaccines

- From Concept to Clinic

af

indgår i serie ACS SYMPOSIUM SERIES

  • Leveringstid 4-6 hverdage
  • Forventet levering 23-10-2019

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