Cancer Stem Cells in Solid Tumors
Format:
Bog, hæftet
Udgivelsesdato:
01-10-2013
Sprog:
Engelsk
  • Beskrivelse
  • Yderligere info
  • Anmeldelser

The "cancer stem cell" hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific "niche"/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs.

 

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.

 

Topics covered include:

Introduction of the CSC hypothesisHistorical perspectives and the contributing lessons from leukemiaCurrent knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCsThe clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistanceConsideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field 

This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Vis mereVis mindre

Udgivelsesdato:
01-10-2013
ISBN13:
9781617797583
Vægt:
689 g
Dybde:
25 mm
Bredde:
156 mm
Højde:
234 mm
Forlag:
Humana Press
Format:
Hæftet
  • Forfattere

    Vis mereVis mindre

    Vis mereVis mindre

    • Leveringstid 4-6 hverdage
    • Forventet levering 25-10-2019

    på lager

    Fandt du ikke hvad du søgte?

    Hvis denne bog ikke er noget for dig, kan du benytte kategorierne nedenfor til at finde andre titler. Klik på en kategori for at se lignende bøger.

    Velkommen til Saxo

    Kom i gang nu!