Blood-Brain Barrier in Drug Discovery

- Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

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Blood-Brain Barrier in Drug Discovery
  • Leveringstid 4-7 hverdage
  • Forventet levering 02-12-2019
Format:
Bog, hardback
Udgivelsesdato:
23-01-2015
Sprog:
Engelsk
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Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. - Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects - Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies - Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes - Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) - Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

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Udgivelsesdato:
23-01-2015
ISBN13:
9781118788356
Vægt:
950 g
Dybde:
36 mm
Bredde:
171 mm
Højde:
245 mm
Format:
Hardback
  • Forfattere

  • Bibliotekernes beskrivelse

    Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant and most challenging areas of drug discovery.

Vis mereVis mindre

Vis mereVis mindre

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